The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity
Selected by
Audrey Noireterre
Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression
Selected by
Yvonne Xinyi Lim
Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features
Selected by
Mariana De Niz
A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2
Selected by
Mariana De Niz
Pharmacological Insights into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Selected by
Zhang-He Goh
A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease
Selected by
Osvaldo Contreras, Alexander Ward
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
AND
Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
Selected by
Zhang-He Goh
Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports
AND
Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia
Selected by
Zhang-He Goh
Identification of neural oscillations and epileptiform changes in human brain organoids
Selected by
Theresa Pohlkamp